Abstract:
The synthesis of metronidazole derivatives [ 1-(2-chloro ethyl)-2-thio formyl methylamino-4-
nitro imidazole, 1-(2-chloro ethyl)-2-thio formyl ethylamino-4-nitro imidazole, 1-ethyl(2-
aniline)-2-thio formyl anilino-4-nitro imidazole, 1-(2-chloro ethyl)-2-thio formyl anilino-4-
nitro imidazole, 1-(2 chloro ethyl)-2-thio formyl para toluidene-4-nitro imidazole] was carried
out using thionyl chloride and amines. The synthesized compounds were characterised using
infrared spectroscopy. The compounds were subjected to antimicrobial tests, it was observed
that compounds produced from primary amines were more reactive against bacteria compared
to my starting material Metronidazole.
